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Unit-I: Antihistaminic and Anti-neoplastic Agents
- Antihistaminic Agents
- Histamine receptors and their distribution in the human body.
- H1-Antagonists: Diphenhydramine hydrochloride, Dimenhydrinate, Doxylamine succinate, Clemastine fumarate, Chlorpheniramine maleate, Triprolidine hydrochloride, Promethazine hydrochloride*, Cyproheptadine hydrochloride, Loratadine, Cetirizine, Levocetirizine, Cromolyn sodium.
- H2-Antagonists: Cimetidine*, Famotidine, Ranitidine.
- Gastric Proton-Pump Inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole.
- Anti-Neoplastic Agents
- Alkylating Agents: Mechlorethamine*, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa.
- Antimetabolites: Mercaptopurine, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate, Azathioprine.
- Antibiotics: Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin.
- Plant Products: Etoposide, Vinblastine sulfate, Vincristine sulfate.
- Miscellaneous: Cisplatin, Mitotane.
Unit-II: Anti-anginal and Vasodilators
- Anti-Anginal Agents
- Vasodilators: Amyl Nitrite, Nitroglycerin, Pentaerythritol tetranitrate, Isosorbide dinitrate, Dipyridamole.
- Calcium Channel Blockers: Verapamil, Bepridil hydrochloride, Diltiazem hydrochloride, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.
Unit-III: Antihypertensive and Diuretics
- Adrenergic Blockers: Prazosin, Terazosin, Doxazosin, Propranolol, Atenolol, Metoprolol, Labetalol.
- ACE Inhibitors: Captopril, Enalapril, Lisinopril, Ramipril.
- Angiotensin II Receptor Blockers (ARBs): Losartan, Valsartan, Irbesartan.
- Diuretics: Acetazolamide, Hydrochlorothiazide, Furosemide, Spironolactone, Amiloride.
Unit-IV: Synthesis and Uses of Heterocyclic Compounds
- Heterocyclic Compounds
- Pyrazole, Imidazole, Oxazole, Thiazole.
- Pyridine, Quinoline, Isoquinoline, Acridine, Indole.
- Pyrimidine, Purine, Azepines and their medicinal significance.
Unit-V: Drug Design and Combinatorial Chemistry
- Drug Design Approaches
- Various approaches in drug design, Quantitative Structure-Activity Relationship (QSAR).
- Physicochemical parameters: Partition coefficient, Hammett’s electronic parameter, Taft’s steric parameter, Hansch analysis.
- Combinatorial Chemistry: Concept and applications, solid-phase and solution-phase synthesis.
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